Hi Ryan,
If you want to use an ODBC on a Mac, you will need setup of the ODBC Driver.
Perhaps you will be able to use an ODBC data source from node-odbc.
You can see the following manuals for ODBC on a Mac.
"Adding the SQL Anywhere ODBC driver (Mac OS x)"
http://dcx.sap.com/index.html#1201/en/dbadmin/add-odbc-driver-mac.html
"Creating an ODBC data source (Mac OS X)"
http://dcx.sap.com/index.html#1201/en/dbadmin/connect-s-3731160.html
Thanks