We are finally making the move from SQL Anywhere 9.0 to 16 - big leap !
I have been running 16 on our test server for over a year and see no problems with the application. One thing I have tested and seems to work is the gradual roll out to each site.
So we have out consolidated server which I am going to leave on 9.0 until the end. I will upgrade each site to 16 in turn. We still use SQL Remote as this has always worked well for us. On the test system I have not seen any problem running different versions of ASA on the consolidated and remote sites - I suppose I'm just looking for re-assurance that this is the case 
. I'm going use this opportunity to increase the page size as well. (will be using -ar for rebuilding.)
Consolidated DB is approx 70GB and we have 10 remote sites.
Any feedback would be welcome.
Mark
